During evolution, chromosome rearrangements, such as reciprocal translocation, transposition and inversion, disrupt gene content and gene order on chromosomes. We discuss algorithmic and statistical approaches to the analysis of comparative genomic data. In a phyloge-netic context, a combined approach is suggested, leading to the median problem for breakpoints. We solve this problem first for the case where all genomes have th same gene content, and then for the general case
From one cell to another, from one individual to another, and from one species to another, the conte...
From one cell to another, from one individual to another, and from one species to another, the conte...
As biological problems are becoming more complex and data growing at a rate much faster than that of...
In this thesis I look at several fundamental mathematical problems in the area of comparative genomi...
Constructing the genomic median of several given genomes is crucial in developing evolutionary trees...
We describe a number of heuristics for inferring the gene orders of the hypothetical ancestral genom...
AbstractIn determining phylogenetic trees using gene order information, medians provide a powerful a...
During the course of evolution, an organism’s genome can undergo changes that affect the large-scale...
In determining phylogenetic trees using gene order information, medians provide a powerful alternati...
In determining phylogenetic trees using gene order information, medians provide a powerful alternati...
Abstract. Genome median and halving problems aim at reconstructing ancestral genomes and the evoluti...
Abstract—During the last years, the genomes of more and more species have been sequenced, providing ...
During the course of evolution, an organism's genome can undergo changes that affect the large-scale...
From one cell to another, from one individual to another, and from one species to another, the conte...
From one cell to another, from one individual to another, and from one species to another, the conte...
From one cell to another, from one individual to another, and from one species to another, the conte...
From one cell to another, from one individual to another, and from one species to another, the conte...
As biological problems are becoming more complex and data growing at a rate much faster than that of...
In this thesis I look at several fundamental mathematical problems in the area of comparative genomi...
Constructing the genomic median of several given genomes is crucial in developing evolutionary trees...
We describe a number of heuristics for inferring the gene orders of the hypothetical ancestral genom...
AbstractIn determining phylogenetic trees using gene order information, medians provide a powerful a...
During the course of evolution, an organism’s genome can undergo changes that affect the large-scale...
In determining phylogenetic trees using gene order information, medians provide a powerful alternati...
In determining phylogenetic trees using gene order information, medians provide a powerful alternati...
Abstract. Genome median and halving problems aim at reconstructing ancestral genomes and the evoluti...
Abstract—During the last years, the genomes of more and more species have been sequenced, providing ...
During the course of evolution, an organism's genome can undergo changes that affect the large-scale...
From one cell to another, from one individual to another, and from one species to another, the conte...
From one cell to another, from one individual to another, and from one species to another, the conte...
From one cell to another, from one individual to another, and from one species to another, the conte...
From one cell to another, from one individual to another, and from one species to another, the conte...
As biological problems are becoming more complex and data growing at a rate much faster than that of...
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