The detection of noncoding transcription at multiple enhancers within the mammalian genome raises critical questions regard-ing whether and how this activity contributes to enhancer function. Here, using in vivo analysis of a human growth hormone (hGH) transgene locus, we report that activation of a domain of noncoding transcription adjacent to the long-range hGH-N en-hancer, HSI, is established by the enhancer independent of any interactions with its target promoter. We further demonstrate that the appearance of this enhancer-linked noncoding transcription is temporally and spatially concordant with induction of hGH-N in the embryonic pituitary. Finally, we show that the level of transcriptional enhancement of hGH-N by HSI is directly rela...
SummaryThe expression of Sonic hedgehog (Shh) in mouse limb buds is regulated by a long-range enhanc...
Genome-wide chromatin profiling efforts have shown that enhancers are often located at large distanc...
Diverse physiological actions of growth hormone (GH) are mediated by changes in gene transcription. ...
The human growth hormone (hGH) gene is controlled by a long-range enhancer, HSI, located 14.5 kb 5′ ...
Transcription of the human growth hormone (hGH) gene depends on cis-acting elements contained within...
For manymammalian genes, initiation of transcription during embryonic development must be subsequent...
Multicellular organisms face a challenge with regard to gene expression: as each individual nucleus ...
The human growth hormone/chorionic somatomammotropin (hGH/hCS) gene cluster contains five highly hom...
Transcription of the human growth hormone gene can start in vitro and in vivo 197 base pairs upstrea...
The expression of the human growth hormone (hGH) gene is regulated by several transcription factors....
The human growth hormone gene ( hGH-N) is regulated by a distal locus control region (LCR) composed ...
In genetics, an enhancer is a short (50-1500 bp) region of DNA that can be bound with proteins (acti...
Activation of the human growth hormone (hGH-N) gene in pituitary somatotropes is mediated by a locus...
Enhancer-associated long noncoding RNAs act over long distances and across chromosomes to activate t...
Enhancer-associated long noncoding RNAs act over long distances and across chromosomes to activate t...
SummaryThe expression of Sonic hedgehog (Shh) in mouse limb buds is regulated by a long-range enhanc...
Genome-wide chromatin profiling efforts have shown that enhancers are often located at large distanc...
Diverse physiological actions of growth hormone (GH) are mediated by changes in gene transcription. ...
The human growth hormone (hGH) gene is controlled by a long-range enhancer, HSI, located 14.5 kb 5′ ...
Transcription of the human growth hormone (hGH) gene depends on cis-acting elements contained within...
For manymammalian genes, initiation of transcription during embryonic development must be subsequent...
Multicellular organisms face a challenge with regard to gene expression: as each individual nucleus ...
The human growth hormone/chorionic somatomammotropin (hGH/hCS) gene cluster contains five highly hom...
Transcription of the human growth hormone gene can start in vitro and in vivo 197 base pairs upstrea...
The expression of the human growth hormone (hGH) gene is regulated by several transcription factors....
The human growth hormone gene ( hGH-N) is regulated by a distal locus control region (LCR) composed ...
In genetics, an enhancer is a short (50-1500 bp) region of DNA that can be bound with proteins (acti...
Activation of the human growth hormone (hGH-N) gene in pituitary somatotropes is mediated by a locus...
Enhancer-associated long noncoding RNAs act over long distances and across chromosomes to activate t...
Enhancer-associated long noncoding RNAs act over long distances and across chromosomes to activate t...
SummaryThe expression of Sonic hedgehog (Shh) in mouse limb buds is regulated by a long-range enhanc...
Genome-wide chromatin profiling efforts have shown that enhancers are often located at large distanc...
Diverse physiological actions of growth hormone (GH) are mediated by changes in gene transcription. ...