Temperament in Child Offspring of Parents with Bipolar Disorder

Objective: The aim of this study was to examine the relationship between temperament and psychopathology in child offspring of parents with bipolar disorder. Method: The Dimensions of Temperament–Revised (DOTS-R) and the Washington University in St. Louis Kid-die Schedule for Affective Disorders and Schizophrenia (WASH U K-SADS) were used to assess temperament and psychopathology, respectively in offspring (8–18 years) of parents with bipolar I disorder (OBP, n! 31) and demographically similar healthy offspring of parents without any Diagnostic and Statistical Manual of Men-tal Disorders, 4th edition (DSM-IV) diagnosis (OHC, n! 21). Results: Compared to OHC, OBP had increased Activity Level–General scores (effect size, d! "0.78), and a trend for decreased Task Orientation (d! "0.78). OBP with mood disorders had trends for decreased Approac