Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2011, Article ID 567305, 6 pages doi:10.1155/2011/567305 Review Article

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. E-Cadherin/β-catenin complex plays an important role in maintaining epithelial integrity and disrupting this complex affect not only the adhesive repertoire of a cell, but also the Wnt-signaling pathway. Aberrant expression of the complex is associated with a wide variety of humanmalignancies and disorders of fibrosis resulting from epithelial-mesenchymal transition. These associations provide insights into the complexity that is likely responsible for the fibrosis/tumor suppressive action of E-cadherin/β-catenin. 1