Proper 39 end processing of a nascent transcript is critical for the functionality of the mature RNA. Although it has long been thought that virtually all long RNA polymerase II transcripts terminate in a poly(A) tail that is generated by endonucleolytic cleavage followed by polyadenylation, noncanonical 39 end processing mechanisms have recently been identified at several gene loci. Unexpectedly, enzymes with well-characterized roles in other RNA processing events, such as tRNA biogenesis and pre-mRNA splicing, cleave these nascent transcripts to generate their mature 39 ends despite the presence of nearby polyadenylation signals. In fact, the presence of multiple potential 39 end cleavage sites is the norm at many human genes, and recent ...
Thesis (Ph.D.)--University of Washington, 2013RNA Polymerase II (PolII) dependent transcription of m...
At the end of protein-coding genes, RNA polymerase (Pol) II undergoes a concerted transition that in...
AbstractThree recent papers reveal a fascinating link between pol II termination and ribonucleolytic...
Transcription termination of nearly all protein-coding genes in mammals requires 3’ end processing b...
The recognition and rapid degradation of mRNAs with premature translation termination codons by the ...
Processing and maturation of precursor RNA species is coupled to RNA polymerase II transcription. Co...
Expression of mature messenger RNAs (mRNAs) requires appropriate transcription initiation and termin...
Polyadenylation [poly(A)] signals (PAS) are a defining feature of eukaryotic protein-coding genes. T...
The life cycle of RNA begins with transcription and ends upon degradation; in between are several pr...
Various signal motifs that are required for efficient pre-mRNA 3*-end formation in the yeast Sacchar...
Copyright © 2015 Paola Munoz-Tello et al. This is an open access article distributed under the Creat...
Termination of pre-mRNA transcription by RNA polymerase II occurs in two steps: a decrease of elonga...
Most eukaryotic mRNAs possess a 7-methyl-guanosine at their 5\u27 ends (5\u27 cap) and a poly(A) tai...
Limiting RNA polymerase II (Pol II) at various stages of the transcription cycle is critical for gen...
Transcriptional termination of mammalian RNA polymerase II (Pol II) requires a poly(A) (pA) signal a...
Thesis (Ph.D.)--University of Washington, 2013RNA Polymerase II (PolII) dependent transcription of m...
At the end of protein-coding genes, RNA polymerase (Pol) II undergoes a concerted transition that in...
AbstractThree recent papers reveal a fascinating link between pol II termination and ribonucleolytic...
Transcription termination of nearly all protein-coding genes in mammals requires 3’ end processing b...
The recognition and rapid degradation of mRNAs with premature translation termination codons by the ...
Processing and maturation of precursor RNA species is coupled to RNA polymerase II transcription. Co...
Expression of mature messenger RNAs (mRNAs) requires appropriate transcription initiation and termin...
Polyadenylation [poly(A)] signals (PAS) are a defining feature of eukaryotic protein-coding genes. T...
The life cycle of RNA begins with transcription and ends upon degradation; in between are several pr...
Various signal motifs that are required for efficient pre-mRNA 3*-end formation in the yeast Sacchar...
Copyright © 2015 Paola Munoz-Tello et al. This is an open access article distributed under the Creat...
Termination of pre-mRNA transcription by RNA polymerase II occurs in two steps: a decrease of elonga...
Most eukaryotic mRNAs possess a 7-methyl-guanosine at their 5\u27 ends (5\u27 cap) and a poly(A) tai...
Limiting RNA polymerase II (Pol II) at various stages of the transcription cycle is critical for gen...
Transcriptional termination of mammalian RNA polymerase II (Pol II) requires a poly(A) (pA) signal a...
Thesis (Ph.D.)--University of Washington, 2013RNA Polymerase II (PolII) dependent transcription of m...
At the end of protein-coding genes, RNA polymerase (Pol) II undergoes a concerted transition that in...
AbstractThree recent papers reveal a fascinating link between pol II termination and ribonucleolytic...