Mus and Peromyscus chromosome homology established by FISH with three mouse paint probes

Abstract. Fluorescence-labeled DNA probes constructed from three whole house mouse (Mus domesticus) chromosomes were hybridized to metaphase spreads from deer mouse (Peromyscus maniculatus) to identify homologies between the species. Mus Chr 7 probe hybridized strongly to the ad-centromeric two-thirds of Peromyscus Chr 1q. Most of Mus 3 probe hybridized principally to two disjunct segments of Peromyscus Chr 3. Mus Chr 9 probe hybridized entirely to the whole Peromyscus Chr 7. Three Pero-myscus linkage groups were assigned to chromosomes, based on linkage homology with Mus. The data also are useful in interpre-tation of chromosomal evolutionary history in myomorphic ro-dents