Maintenance of lymphoid homeostasis in a number of immunological and inflammatory contexts is served by a variety of regulatory T (Treg) cell subtypes, and depends on interaction of the transcription factor Foxp3 with specific transcriptional cofactors. We report that a commonly used insertional mutant of FoxP3 (GFP-Foxp3) modified its molecular interactions, blocking Hif1a but increasing Irf4 interactions. The transcriptional profile of these Treg cells was subtly altered, with an over-representation of Irf4-dependent transcripts. In keeping with Irf4-dependent function of Treg cells to preferentially suppress T cell help to B cells and Th2- and Th17-type differentiation, GFP-Foxp3 mice showed a divergent susceptibility to autoimmune disea...
Maintenance of immune homeostasis is a complex process allowing the immune system to be both aggress...
Foxp3-expressing regulatory T (Treg) cells suppress pathology mediated by immune responses against s...
Forkhead box P3 (Foxp3) is an important transcription factor that belongs to the forkhead/winged-hel...
SummaryMaintenance of lymphoid homeostasis in a number of immunological and inflammatory contexts is...
T regulatory (Treg) cells expressing the transcription factor FoxP3 play a key role in protection ag...
Accumulating evidence suggests that defective regulation is an essential underlying cause of autoimm...
A balanced immune response requires tight control of immune activation at various levels, which cruc...
SummaryRegulatory T (Treg) cells, driven by the Foxp3 transcription factor, are responsible for limi...
The involvement of regulatory T cells (Tregs) in immune homeostasis is now recognized as one of the ...
DoctorRegulatory T (Treg) cells, a distinct subset of CD4+ T cells that are essential for maintainin...
The discovery of the transcription factor Forkhead box-p3 (Foxp3) has shed fundamental insights into...
Abstract The discovery of the transcription factor Forkhead box-p3 (Foxp3) has shed fundamental ins...
Regulatory T (Treg) cells play an essential role in maintaining immunological tolerance. The discove...
Regulatory T-cells (TREG) are diverse populations of lymphocytes that regulate the adaptive immune r...
Regulatory T cells (Treg) are a specialized subpopulation of T cells that play a key role in maintai...
Maintenance of immune homeostasis is a complex process allowing the immune system to be both aggress...
Foxp3-expressing regulatory T (Treg) cells suppress pathology mediated by immune responses against s...
Forkhead box P3 (Foxp3) is an important transcription factor that belongs to the forkhead/winged-hel...
SummaryMaintenance of lymphoid homeostasis in a number of immunological and inflammatory contexts is...
T regulatory (Treg) cells expressing the transcription factor FoxP3 play a key role in protection ag...
Accumulating evidence suggests that defective regulation is an essential underlying cause of autoimm...
A balanced immune response requires tight control of immune activation at various levels, which cruc...
SummaryRegulatory T (Treg) cells, driven by the Foxp3 transcription factor, are responsible for limi...
The involvement of regulatory T cells (Tregs) in immune homeostasis is now recognized as one of the ...
DoctorRegulatory T (Treg) cells, a distinct subset of CD4+ T cells that are essential for maintainin...
The discovery of the transcription factor Forkhead box-p3 (Foxp3) has shed fundamental insights into...
Abstract The discovery of the transcription factor Forkhead box-p3 (Foxp3) has shed fundamental ins...
Regulatory T (Treg) cells play an essential role in maintaining immunological tolerance. The discove...
Regulatory T-cells (TREG) are diverse populations of lymphocytes that regulate the adaptive immune r...
Regulatory T cells (Treg) are a specialized subpopulation of T cells that play a key role in maintai...
Maintenance of immune homeostasis is a complex process allowing the immune system to be both aggress...
Foxp3-expressing regulatory T (Treg) cells suppress pathology mediated by immune responses against s...
Forkhead box P3 (Foxp3) is an important transcription factor that belongs to the forkhead/winged-hel...