Add to ORKGIn the classic paradigm of mammalian cell cycle control, Rb functions to restrict cells from entering S phase by sequestering E2F activators (E2f1, E2f2 and E2f3), which are invariably portrayed as the ultimate effectors of a transcriptional program that commit cells to enter and progress through S phase1, 2. Using a panel of tissue-specific cre-transgenic mice and conditional E2f alleles we examine the effects of E2f1, E2f2 and E2f3 triple deficiency in murine ES cells
While genetically engineered mice have made an enormous contribution towards the elucidation of huma...
AbstractE2F activity is crucial for the G1/S transition and DNA replication in mammalian cells. The ...
E2F transcription factors are thought to influence the G1-S cell-cycle transition by controlling exp...
In the established model of mammalian cell cycle control, the retinoblastoma protein (Rb) functions ...
In the established model of mammalian cell cycle control, the retinoblastoma protein (Rb) functions ...
The E2f3 locus encodes two Rb-binding gene products, E2F3a and E2F3b, which are differentially regul...
RB-E2F transcriptional control plays a key role in regulating the timing of cell cycle progression f...
RB-E2F transcriptional control plays a key role in regulating the timing of cell cycle progression f...
been hypothesized to play a role inactivating the expres-5Department of Neurobiology sion of genes i...
International audienceRobust mechanisms to control cell proliferation have evolved to maintain the i...
(A) Mouse embryonic fibroblasts (MEFs) were serum starved for 60 hours. Relative transcript levels w...
The pRB family, which includes p107 and p130 are known to control cell proliferation and differentia...
E2F transcription factors are central regulators of cell division and cell fate decisions. E2F4 ofte...
The tumor suppressor function of Rb is intimately related to its ability to interact with E2F and re...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2003.Includes bibliographi...
While genetically engineered mice have made an enormous contribution towards the elucidation of huma...
AbstractE2F activity is crucial for the G1/S transition and DNA replication in mammalian cells. The ...
E2F transcription factors are thought to influence the G1-S cell-cycle transition by controlling exp...
In the established model of mammalian cell cycle control, the retinoblastoma protein (Rb) functions ...
In the established model of mammalian cell cycle control, the retinoblastoma protein (Rb) functions ...
The E2f3 locus encodes two Rb-binding gene products, E2F3a and E2F3b, which are differentially regul...
RB-E2F transcriptional control plays a key role in regulating the timing of cell cycle progression f...
RB-E2F transcriptional control plays a key role in regulating the timing of cell cycle progression f...
been hypothesized to play a role inactivating the expres-5Department of Neurobiology sion of genes i...
International audienceRobust mechanisms to control cell proliferation have evolved to maintain the i...
(A) Mouse embryonic fibroblasts (MEFs) were serum starved for 60 hours. Relative transcript levels w...
The pRB family, which includes p107 and p130 are known to control cell proliferation and differentia...
E2F transcription factors are central regulators of cell division and cell fate decisions. E2F4 ofte...
The tumor suppressor function of Rb is intimately related to its ability to interact with E2F and re...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2003.Includes bibliographi...
While genetically engineered mice have made an enormous contribution towards the elucidation of huma...
AbstractE2F activity is crucial for the G1/S transition and DNA replication in mammalian cells. The ...
E2F transcription factors are thought to influence the G1-S cell-cycle transition by controlling exp...