Topics
amineBand
CelecoxibChemical substance
celecoxibChemical substance
hepatic carcinomaDisease
acidChemical compound
Abstract: Herein, novel hybrid compounds of celecoxib and 2-aminoanthraquinone derivatives have been synthesized using condensation reactions of celecoxib with 2-aminoanthraquinone derivatives or 2-aminoanthraquinon with celecoxib derivatives. Celecoxib was reacted with different acid chlorides, 2-chloroethylisocyanate and bis (2-chloroethyl) amine hydrochloride. These intermediates were then reacted with 2-aminoanthraquinone. Also the same different acid chlorides and 2-chloroethylisocyanate were reacted with 2-aminoanthraquinone and the resulting intermediates were reacted with celecoxib to give isomers for the previous compounds. The antitumor activities against hepatic carcinoma tumor cell line (HEPG2
The quinoxaline scaffold is a promising platform for the discovery of active chemotherapeutic agents...
International audienceWe report a novel series of quinoxaline derivatives from which agents with ant...
In our search for new anticancer therapies, some compounds synthesized in our lab were selected and ...
Herein, novel hybrid compounds of celecoxib and 2-aminoanthraquinone derivatives have been synthesiz...
A novel series of 1,4-disubstituted aminoanthraquinones were prepared by ipso-displacement of 1,4-di...
A series of novel N-(3-substituted aryl/alkyl-4-oxo-1,3-thiazolidin-2-ylidene)-4-[5-(4-methylphenyl)...
A series of novel N-(3-substituted aryl/alkyl-4-oxo-1,3-thiazolidin-2-ylidene)-4-[5-(4-methylphenyl)...
Novel 1- and 1,4-substituted chloroethylaminoanthraquinones with DNA binding and alkylating properti...
NoNovel 1- and 1,4-substituted chloroethylaminoanthraquinones with DNA binding and alkylating proper...
Aminoanthraquinones were successfully synthesized via two reaction steps. 1,4-Dihydroxyanthraquinone...
A series of 23 novel anthraquinone-chalcone hybrids containing amide function was synthesized and st...
A series of aminoanthraquinone derivatives were synthesized via two reaction steps. The starting mat...
ObjectivesThe cyclooxygenase 2 enzyme has become a therapeutic target in cancer treatment. Cyclooxyg...
10The combination of two pharmacophores into a single molecule represents one of the methods that ca...
A new series of hybrid molecules containing cinnamic acid and 2-quinolinone derivatives were designe...
The quinoxaline scaffold is a promising platform for the discovery of active chemotherapeutic agents...
International audienceWe report a novel series of quinoxaline derivatives from which agents with ant...
In our search for new anticancer therapies, some compounds synthesized in our lab were selected and ...
Herein, novel hybrid compounds of celecoxib and 2-aminoanthraquinone derivatives have been synthesiz...
A novel series of 1,4-disubstituted aminoanthraquinones were prepared by ipso-displacement of 1,4-di...
A series of novel N-(3-substituted aryl/alkyl-4-oxo-1,3-thiazolidin-2-ylidene)-4-[5-(4-methylphenyl)...
A series of novel N-(3-substituted aryl/alkyl-4-oxo-1,3-thiazolidin-2-ylidene)-4-[5-(4-methylphenyl)...
Novel 1- and 1,4-substituted chloroethylaminoanthraquinones with DNA binding and alkylating properti...
NoNovel 1- and 1,4-substituted chloroethylaminoanthraquinones with DNA binding and alkylating proper...
Aminoanthraquinones were successfully synthesized via two reaction steps. 1,4-Dihydroxyanthraquinone...
A series of 23 novel anthraquinone-chalcone hybrids containing amide function was synthesized and st...
A series of aminoanthraquinone derivatives were synthesized via two reaction steps. The starting mat...
ObjectivesThe cyclooxygenase 2 enzyme has become a therapeutic target in cancer treatment. Cyclooxyg...
10The combination of two pharmacophores into a single molecule represents one of the methods that ca...
A new series of hybrid molecules containing cinnamic acid and 2-quinolinone derivatives were designe...
The quinoxaline scaffold is a promising platform for the discovery of active chemotherapeutic agents...
International audienceWe report a novel series of quinoxaline derivatives from which agents with ant...
In our search for new anticancer therapies, some compounds synthesized in our lab were selected and ...
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