CD40 is essential for optimal B cell activation. It has been shown that CD40 stimulation can augment BCR-induced B cell responses, but the molecular mechanism(s) by which CD40 regulates BCR signaling is poorly understood. In this report, we attempted to characterize the signaling synergy between BCR- and CD40-mediated pathways during B cell activation. We found that spleen tyrosine kinase (Syk) is involved in CD40 signaling, and is synergistically activated in B cells in response to BCR/CD40 costimulation. CD40 stimulation alone also activates B cell linker (BLNK), Bruton tyrosine kinase (Btk), and Vav-2 downstream of Syk, and significantly enhances BCR-induced formation of complex consisting of, Vav-2, Btk, BLNK, and phospholipase C-gamma2...
Conventionally, signaling through BCR initiates sequence of events necessary for activation and diff...
AbstractThe interaction of the CD40 receptor with its ligand has been shown to be crucial for the ac...
Spleen tyrosine kinase (Syk), a 72 kD non-receptor tyrosine kinase, is expressed in most hematopoiet...
B lymphocytes need two signals in order to differentiate into antibody-producing cells, one deliver...
grantor: University of TorontoStimulation of CD40 activates several signal transduction pa...
Development, survival, and activation of B lymphocytes are controlled by signals emanating from the ...
The protein tyrosine kinase Syk couples the B-cell receptor (BCR) for antigen to multiple intracellu...
Engagement of B cell receptors evokes a cascade of signaling events leading to clonal expansion, dif...
International audienceHuman CD21low B cells present with an activated phenotype and accumulate in di...
Antibodies are specialized molecules produced by B-lymphocytes to combat infection by binding to and...
AbstractCD40 is a receptor that is critical for the survival, growth, differentiation, and isotype s...
B lymphocytes can be activated by many different stimuli. However, the mechanisms responsible for th...
CD40 is a member of the growing tumor necrosis factor receptor (TNF-R) family of molecules, and has ...
How diverse environmental cues are inte-grated to regulate B-cell activation and development remains...
The development and function of B lymphocytes is regulated by numerous signaling pathways, some eman...
Conventionally, signaling through BCR initiates sequence of events necessary for activation and diff...
AbstractThe interaction of the CD40 receptor with its ligand has been shown to be crucial for the ac...
Spleen tyrosine kinase (Syk), a 72 kD non-receptor tyrosine kinase, is expressed in most hematopoiet...
B lymphocytes need two signals in order to differentiate into antibody-producing cells, one deliver...
grantor: University of TorontoStimulation of CD40 activates several signal transduction pa...
Development, survival, and activation of B lymphocytes are controlled by signals emanating from the ...
The protein tyrosine kinase Syk couples the B-cell receptor (BCR) for antigen to multiple intracellu...
Engagement of B cell receptors evokes a cascade of signaling events leading to clonal expansion, dif...
International audienceHuman CD21low B cells present with an activated phenotype and accumulate in di...
Antibodies are specialized molecules produced by B-lymphocytes to combat infection by binding to and...
AbstractCD40 is a receptor that is critical for the survival, growth, differentiation, and isotype s...
B lymphocytes can be activated by many different stimuli. However, the mechanisms responsible for th...
CD40 is a member of the growing tumor necrosis factor receptor (TNF-R) family of molecules, and has ...
How diverse environmental cues are inte-grated to regulate B-cell activation and development remains...
The development and function of B lymphocytes is regulated by numerous signaling pathways, some eman...
Conventionally, signaling through BCR initiates sequence of events necessary for activation and diff...
AbstractThe interaction of the CD40 receptor with its ligand has been shown to be crucial for the ac...
Spleen tyrosine kinase (Syk), a 72 kD non-receptor tyrosine kinase, is expressed in most hematopoiet...