Add to ORKGThe Author(s) 2013. This article is published with open access at Springerlink.com Abstract Longevity and healthy aging are among the most complex phenotypes studied to date. The heritability of age at death in adulthood is approximately 25 %. Studies of exceptionally long-lived individuals show that herita-bility is greatest at the oldest ages. Linkage studies of exceptionally long-lived families now support a longevity locus on chromosome 3; other putative longevity loci differ between studies. Candidate gene studies have identified variants at APOE and FOXO3A associated with longevity; other genes show inconsistent results. Genome-wide asso-ciation scans (GWAS) of centenarians vs. younger controls reveal only APOE as achieving genome-wid...
Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. He...
Clear evidence exists for heritability of humanlongevity, and much interest is focused on identifyin...
BACKGROUND: Family studies and heritability estimates provide evidence for a genetic contribution to...
: Several studies on the genetics of longevity have been reviewed in this paper. The results show th...
textabstractBackground. The genetic contribution to longevity in humans has been estimated to range ...
By studying the loci that contribute to human longevity, we aim to identify mechanisms that contribu...
Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet the ide...
BackgroundThe genetic contribution to longevity in humans has been estimated to range from 15% to 25...
Background. The genetic contribution to longevity in humans has been estimated to range from 15% to ...
Clear evidence exists for heritability of human longevity, and much interest is focused on identifyi...
Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. He...
We developed a new statistical framework to find genetic variants associated with extreme longevity....
<div><p>We developed a new statistical framework to find genetic variants associated with extreme lo...
Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. He...
Clear evidence exists for heritability of humanlongevity, and much interest is focused on identifyin...
BACKGROUND: Family studies and heritability estimates provide evidence for a genetic contribution to...
: Several studies on the genetics of longevity have been reviewed in this paper. The results show th...
textabstractBackground. The genetic contribution to longevity in humans has been estimated to range ...
By studying the loci that contribute to human longevity, we aim to identify mechanisms that contribu...
Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet the ide...
BackgroundThe genetic contribution to longevity in humans has been estimated to range from 15% to 25...
Background. The genetic contribution to longevity in humans has been estimated to range from 15% to ...
Clear evidence exists for heritability of human longevity, and much interest is focused on identifyi...
Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. He...
We developed a new statistical framework to find genetic variants associated with extreme longevity....
<div><p>We developed a new statistical framework to find genetic variants associated with extreme lo...
Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. He...
Clear evidence exists for heritability of humanlongevity, and much interest is focused on identifyin...
BACKGROUND: Family studies and heritability estimates provide evidence for a genetic contribution to...