Add to ORKGMutation of leucine-rich repeat kinase 2 (LRRK2) is the leading genetic cause of Parkinson’s Disease (PD), manifested as age-dependent dopaminergic neurodegeneration, but the underlying molecular mechanisms remain unclear. Multiple roles of LRRK2 may contribute to dopaminergic neurodegeneration. Endoplasmic reticulum (ER) stress has also been linked to PD pathogenesis, but its interactive mechanism with PD genetic factors is largely unknown. Here, we used C. elegans, human neuroblastoma cells and murine cortical neurons to determine the role of LRRK2 in maintaining dopaminergic neuron viability. We found that LRRK2 acts to protect neuroblastoma cells and C. elegans dopaminergic neurons from the toxicity of 6-hydroxydopamine and/or human a-s...
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease with a similar clinical ...
LRRK2 is a protein that interacts with a plethora of signaling molecules, but the complexity of LRRK...
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent known cause of late-onset Pa...
Mutation of leucine-rich repeat kinase 2 (LRRK2) is the leading genetic cause of Parkinson's Disease...
Mutations in leucine-rich repeat kinase 2 (LRRK2) are common causes of familial Parkinson’s disease ...
SummaryThe LRRK2 mutation G2019S is the most common genetic cause of Parkinson’s disease (PD). To be...
The LRRK2 mutation G2019S is the most common genetic cause of Parkinson's disease (PD). To better un...
The LRRK2 mutation G2019S is the most common genetic cause of Parkinson’s disease (PD). To better un...
Parkinson’s disease (PD) is the second most common neurodegenerative disorder. Its cause(s) are pred...
peer reviewedMutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause familial as well as sp...
By combining experimental neuron models and mathematical tools, we developed a "systems" approach to...
Mutations in leucine-rich repeat kinase 2 (LRRK2) are common causes of familial Parkinson’s disease ...
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent known cause of late-onset Pa...
This journal suppl. contatin Abstracts of WFN XIX World Congress on Parkinson's Disease and Related ...
Mutations in PARK8, encoding leucine-rich repeat kinase 2 (LRRK2), are a major cause of Parkinson's ...
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease with a similar clinical ...
LRRK2 is a protein that interacts with a plethora of signaling molecules, but the complexity of LRRK...
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent known cause of late-onset Pa...
Mutation of leucine-rich repeat kinase 2 (LRRK2) is the leading genetic cause of Parkinson's Disease...
Mutations in leucine-rich repeat kinase 2 (LRRK2) are common causes of familial Parkinson’s disease ...
SummaryThe LRRK2 mutation G2019S is the most common genetic cause of Parkinson’s disease (PD). To be...
The LRRK2 mutation G2019S is the most common genetic cause of Parkinson's disease (PD). To better un...
The LRRK2 mutation G2019S is the most common genetic cause of Parkinson’s disease (PD). To better un...
Parkinson’s disease (PD) is the second most common neurodegenerative disorder. Its cause(s) are pred...
peer reviewedMutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause familial as well as sp...
By combining experimental neuron models and mathematical tools, we developed a "systems" approach to...
Mutations in leucine-rich repeat kinase 2 (LRRK2) are common causes of familial Parkinson’s disease ...
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent known cause of late-onset Pa...
This journal suppl. contatin Abstracts of WFN XIX World Congress on Parkinson's Disease and Related ...
Mutations in PARK8, encoding leucine-rich repeat kinase 2 (LRRK2), are a major cause of Parkinson's ...
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease with a similar clinical ...
LRRK2 is a protein that interacts with a plethora of signaling molecules, but the complexity of LRRK...
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent known cause of late-onset Pa...