Add to ORKGDisruptions in brain-derived neurotrophic factor (BDNF) expression are proposed to contribute to the molecular pathogenesis of Rett syndrome (RTT), a severe neurological disorder caused by loss-of-function mutations in methyl-CpG-binding protein-2 (MeCP2). Al-though MeCP2 is a transcriptional regulator of BDNF, it is unknown how MeCP2 mutations affect transynaptic BDNF signaling. Our findingsdemonstrate anearly, abnormalneurosecretoryphenotype inMeCP2-deficientneurons characterizedby significant increases in thepercentageof cellularBDNFcontent available for release.However, lossofMeCP2also results indeficits in total cell BDNFcontent that are developmentally regulated in a cell-type-specificmanner. Thus, the net effect ofMeCP2 loss on absol...
International audienceBACKGROUND: Rett syndrome (RTT, MIM #312750) is a severe neurological disorder...
Introduction: Methyl cytosine protein binding 2 (MECP2) binds preferentially to methylated CpGs and ...
Rett syndrome is a neurodevelopmental disorder that is predominately caused by mutations of the MECP...
Mutations in the MECP2 gene cause the neurodevelopmental disorder Rett syndrome (RTT). Previous stud...
SummaryMutations in the MECP2 gene cause Rett syndrome (RTT). Bdnf is a MeCP2 target gene; however, ...
Mutations in the MECP2 gene cause the neurodevelopmental disorder Rett syndrome (RTT). Previous stud...
Mutations in MECP2 are responsible for Rett syndrome (RTT), a severe X-linked neurological disorder ...
Mutations in MECP2 are responsible for Rett syndrome (RTT), a severe X-linked neurological disorder ...
Genetic mutations of the X-linked gene MECP2, encoding methyl-CpG-binding protein 2, cause Rett synd...
Rett syndrome (RTT) is an X-linked postnatal neurodevelopmental disorder, which is primarily caused ...
g.oxfordjournals.org/ D ow nloaded from 2 Rett syndrome (RTT) is caused by mutations in the gene enc...
Rett syndrome (RTT), a rare neurodevelopmental disease found in 1:15,000 of female births, is an aut...
Rett syndrome (RTT) is a severe neurological disorder caused by mutations in the gene encoding methy...
The postnatal neurodevelopmental disorder Rett syndrome (RTT) is caused by mutations in the gene enc...
Mutations in the gene encoding the methyl-CpG-binding protein MECP2 are the major cause of Rett synd...
International audienceBACKGROUND: Rett syndrome (RTT, MIM #312750) is a severe neurological disorder...
Introduction: Methyl cytosine protein binding 2 (MECP2) binds preferentially to methylated CpGs and ...
Rett syndrome is a neurodevelopmental disorder that is predominately caused by mutations of the MECP...
Mutations in the MECP2 gene cause the neurodevelopmental disorder Rett syndrome (RTT). Previous stud...
SummaryMutations in the MECP2 gene cause Rett syndrome (RTT). Bdnf is a MeCP2 target gene; however, ...
Mutations in the MECP2 gene cause the neurodevelopmental disorder Rett syndrome (RTT). Previous stud...
Mutations in MECP2 are responsible for Rett syndrome (RTT), a severe X-linked neurological disorder ...
Mutations in MECP2 are responsible for Rett syndrome (RTT), a severe X-linked neurological disorder ...
Genetic mutations of the X-linked gene MECP2, encoding methyl-CpG-binding protein 2, cause Rett synd...
Rett syndrome (RTT) is an X-linked postnatal neurodevelopmental disorder, which is primarily caused ...
g.oxfordjournals.org/ D ow nloaded from 2 Rett syndrome (RTT) is caused by mutations in the gene enc...
Rett syndrome (RTT), a rare neurodevelopmental disease found in 1:15,000 of female births, is an aut...
Rett syndrome (RTT) is a severe neurological disorder caused by mutations in the gene encoding methy...
The postnatal neurodevelopmental disorder Rett syndrome (RTT) is caused by mutations in the gene enc...
Mutations in the gene encoding the methyl-CpG-binding protein MECP2 are the major cause of Rett synd...
International audienceBACKGROUND: Rett syndrome (RTT, MIM #312750) is a severe neurological disorder...
Introduction: Methyl cytosine protein binding 2 (MECP2) binds preferentially to methylated CpGs and ...
Rett syndrome is a neurodevelopmental disorder that is predominately caused by mutations of the MECP...