CASE REPORT Open Access t h

Full list of author information is available at the end of the articleA spontaneous closure of an idiopathic full-thickness macular hole (MH) occasionally occurs [1,2]. Examining the structural changes of the retina that lead to the clos-ure, especially what types of cells are involved in plugging the MH, would help in the understanding of the me-chanisms and the cells involved in the spontaneous closures. Although no histopathologic studies of spontaneously and completely closed idiopathic full-thickness MHs have been published, clinicopathological reports regarding astrocytes would be the most likely candidates in the re-pair of a MH [3,4]. Several investigators have followed the processes involved in the closure of a MH and restoration of the macular architecture by optical coherence tomog-raphy (OCT) [5-7]. However, the cells involved in the early structural changes that form the bridge over a MH have still not been determined conclusively. We document the sequence of structural changes, including the early changes, that occur during a spontan-eous closure of idiopathic full-thickness MH by spectral-domain OCT (SD-OCT). Our findings suggest that Müller * Correspondence