Rotation Frequency of Human Bronchial and Nasal Epithelial Spheroids as an Indicator of Mucociliary Function

because the byproducts from photolysis negatively af-fected ciliary function. The transport velocity at the sur-face of bronchial and nasal spheroids was estimated to be 2.96 and 3.62 mm/min (medians), respectively, which is in the same range as mucus transport velocity mea-sured in vivo in humans. Conclusions: This setup can be used to study mucociliary transport function under con-trolled conditions in vitro, in particular as RF is likely to refl ect not only ciliary beat frequency, but also the coor-dination of ciliary beating and the properties of the mucus. Copyright © 2006 S. Karger AG, Base