EARLY ELEVATION IN RANDOM PLASMA IL-6 FOLLOWING SEVERE INJURY IS ASSOCIATED WITH DEVELOPMENT OF

Background—Excessive pro-inflammatory activation following trauma plays a role in late morbidity and mortality including the development of multiple organ dysfunction syndrome (MODS). To date, identification of patients at risk has been challenging. Results from animal and human studies suggest that circulating IL-6, may serve as a biomarker for excessive inflammation. The purpose of this analysis was to determine the association of IL-6 to outcome in a multi-center developmental cohort and in a single-center validation cohort. Methods—Severely injured patients with shock due to hemorrhage were evaluated within a multi-center developmental cohort (n=79). All had blood drawn within 12 hours of injury. Plasma IL-6 was determined by multiplex proteomic analysis. Clinical and outcome data were prospectively obtained. Within this developmental cohort, a plasma IL-6 level was determined fo