Thrombospondin 2 (TSP2) can inhibit angiogenesis in vitro by limiting proliferation and inducing apoptosis of endothelial cells (ECs). TSP2 can also modulate the extracellular levels of gelatinases (matrix metallopro-teases, MMPs) and potentially influence the remodel-ing of the extracellular matrix (ECM). Here, we tested the hypothesis that by regulating MMPs, TSP2 could alter EC-ECM interactions. By using a three-dimen-sional angiogenesis assay, we show that TSP2, but not TSP1, limited angiogenesis by decreasing gelatino-lytic activity in situ. Furthermore, TSP2-null fibro-blast-derived ECM, which contains irregular collagen fibrils, was more permissive for EC migration. Inves-tigation of the role of TSP2 in physiological angiogen-esis in...
We have previously reported that tissue inhibitor of metalloproteinases-2 (TIMP-2), an endogenous in...
AbstractAngiogenesis depends on both cell adhesion and proteolytic mechanisms. In fact, matrix metal...
Formation of new blood vessels (angiogenesis) is a key step during the development of various pathol...
The hypothesis that thrombospondin-1 (TSP-1) can exert opposite effects on angiogenesis depending o...
The antiangiogenic factor thrombospondin 1 (TSP-1) binds with high affinity to several heparin-bindi...
AbstractIntroduction: Thrombospondin-1 (TSP-1), an extracellular matrix (ECM) glycoprotein, is assoc...
AbstractTissue inhibitors of metalloproteinases (TIMPs) suppress matrix metalloproteinase (MMP) acti...
Thrombospondin 2 (TSP2)-null mice, generated by targeted disruption of the Thbs2 gene, display a com...
Thrombospondins TSP-1 and TSP-2 are potent endogenous inhibitors of angiogenesis. They inhibit angio...
Thrombospondin-l (TSPl) is a multidomain glycoprotein expressed by many cell types. It is a multifun...
We found that thrombospondin-1 (TSP-1) has opposite functions on angiogenesis depending on the natur...
Abstract: Thrombospondin (TSP) is an anti-angiogenic protein that inhibits vascular endothelial grow...
Coronary collateral circulation plays a protective role in patients with coronary artery disease (CA...
Thrombospondins (TSPs) are a family of extracellular matrix proteins that regulate tissue genesis an...
The importance of tissue transglutaminase (TG2) in angiogenesis is unclear and contradictory. Here w...
We have previously reported that tissue inhibitor of metalloproteinases-2 (TIMP-2), an endogenous in...
AbstractAngiogenesis depends on both cell adhesion and proteolytic mechanisms. In fact, matrix metal...
Formation of new blood vessels (angiogenesis) is a key step during the development of various pathol...
The hypothesis that thrombospondin-1 (TSP-1) can exert opposite effects on angiogenesis depending o...
The antiangiogenic factor thrombospondin 1 (TSP-1) binds with high affinity to several heparin-bindi...
AbstractIntroduction: Thrombospondin-1 (TSP-1), an extracellular matrix (ECM) glycoprotein, is assoc...
AbstractTissue inhibitors of metalloproteinases (TIMPs) suppress matrix metalloproteinase (MMP) acti...
Thrombospondin 2 (TSP2)-null mice, generated by targeted disruption of the Thbs2 gene, display a com...
Thrombospondins TSP-1 and TSP-2 are potent endogenous inhibitors of angiogenesis. They inhibit angio...
Thrombospondin-l (TSPl) is a multidomain glycoprotein expressed by many cell types. It is a multifun...
We found that thrombospondin-1 (TSP-1) has opposite functions on angiogenesis depending on the natur...
Abstract: Thrombospondin (TSP) is an anti-angiogenic protein that inhibits vascular endothelial grow...
Coronary collateral circulation plays a protective role in patients with coronary artery disease (CA...
Thrombospondins (TSPs) are a family of extracellular matrix proteins that regulate tissue genesis an...
The importance of tissue transglutaminase (TG2) in angiogenesis is unclear and contradictory. Here w...
We have previously reported that tissue inhibitor of metalloproteinases-2 (TIMP-2), an endogenous in...
AbstractAngiogenesis depends on both cell adhesion and proteolytic mechanisms. In fact, matrix metal...
Formation of new blood vessels (angiogenesis) is a key step during the development of various pathol...