such as circadian changes [4] but also under inflamma-tory conditions where disturbance of these axes induces increases in circulating myeloid cells and worsening of inflammatory diseases [5, 6]. The molecular mechanisms underlying the control of neutrophil homeostasis in steady-state and inflammatory conditions are reviewed in detail by Strydom and Rankin [7]. Neutrophils are the first leukocyte subset recruited to sites of inflammation. In the absence of microbial stimu-li, i.e. in sterile inflammation, damage-associated molec-ular patterns (DAMPs) represent the trigger for neutro-phil emigration. Important DAMPs are extracellular ATP [8, 9] , mitochondrial formylated peptides [10] and DNA [11] , all of which are released by dying cells. ...
Neutrophils, key cells of the innate immune system, are responsible for preventing bacterial infecti...
ABSTR ACT: Neutrophils (also called polymorphonuclear leukocytes, PMNs) are the most abundant white ...
Neutrophils are key innate immune effector cells that are rapidly recruited to sites of infection an...
Recognizing the importance of leukocyte trafficking in inflammation led to some therapeutic breakthr...
Neutrophils eliminate pathogens efficiently but can inflict severe damage to the host if they over-a...
Injury causes a systemic inflammatory response syndrome (SIRS) clinically much like sepsis 1. Microb...
Rhythms in immunity manifest in multiple ways, but perhaps most prominently by the recurrent onset o...
Immune protection relies on the capacity of neutrophils to infiltrate challenged tissues. Naive tiss...
SummaryUnique among leukocytes, neutrophils follow daily cycles of release from and migration back i...
Neutrophils not only play a critical role as a first line of defense against bacteria and fungi infe...
Immune protection relies on the capacity of neutrophils to infiltrate challenged tissues. Naive tiss...
The antimicrobial functions of neutrophils are facilitated by a defensive armamentarium of proteins ...
Systemic inflammation is a hallmark of trauma, sepsis and various severe infectious diseases. Severe...
Neutrophils, key cells of the innate immune system, are responsible for preventing bacterial infecti...
ABSTR ACT: Neutrophils (also called polymorphonuclear leukocytes, PMNs) are the most abundant white ...
Neutrophils are key innate immune effector cells that are rapidly recruited to sites of infection an...
Recognizing the importance of leukocyte trafficking in inflammation led to some therapeutic breakthr...
Neutrophils eliminate pathogens efficiently but can inflict severe damage to the host if they over-a...
Injury causes a systemic inflammatory response syndrome (SIRS) clinically much like sepsis 1. Microb...
Rhythms in immunity manifest in multiple ways, but perhaps most prominently by the recurrent onset o...
Immune protection relies on the capacity of neutrophils to infiltrate challenged tissues. Naive tiss...
SummaryUnique among leukocytes, neutrophils follow daily cycles of release from and migration back i...
Neutrophils not only play a critical role as a first line of defense against bacteria and fungi infe...
Immune protection relies on the capacity of neutrophils to infiltrate challenged tissues. Naive tiss...
The antimicrobial functions of neutrophils are facilitated by a defensive armamentarium of proteins ...
Systemic inflammation is a hallmark of trauma, sepsis and various severe infectious diseases. Severe...
Neutrophils, key cells of the innate immune system, are responsible for preventing bacterial infecti...
ABSTR ACT: Neutrophils (also called polymorphonuclear leukocytes, PMNs) are the most abundant white ...
Neutrophils are key innate immune effector cells that are rapidly recruited to sites of infection an...