Add to ORKGAbstract: Aldehyde dehydrogenase 1 (ALDH1) is reported as a biomarker for identifying some cancer stem cells, and down-regulation or inhibition of the enzyme can be effective in anti-drug resistance and a potent therapeutic for some tumours. In this paper, the inhibitory activity, mechanism mode, molecular docking and 3D-QSAR (three-dimensional quantitative structure activity relationship) of curcumin analogues (CAs) against ALDH1 were studied. Results demonstrated that curcumin and CAs possessed potent inhibitory activity against ALDH1, and the CAs compound with ortho di-hydroxyl groups showed the most potent inhibitory activity. This study indicates that CAs may represent a new class of ALDH1 inhibitor
Introduction: Curcumin (Diferuloylmethane) is a natural phenolic compound, which belongs to the curc...
Abstract. Curcumin has been widely reported as an anti-inflammatory agent isolated from the plant Cu...
In the present study, we aimed to dock 17 different ligands of curcumin analogues with that of human...
Aldehyde dehydrogenase 1 (ALDH1) is reported as a biomarker for identifying some cancer stem cells, ...
Abstract: Androgen receptor antagonists have been proved to be effective anti-prostate cancer agents...
Abstract: The antioxidative properties of a novel curcumin analogue (2E,6E)-2,6-bis(3,5-dimethoxyben...
Aldose reductase (ALR2) inhibition is the most legitimate approach for the management of diabetic co...
Objective: In the current study, an in silico approach has been utilized to investigate the anti-SAR...
A series of novel curcumin analogues has been designed, synthesized and tested in vitro/in vivo as p...
Curcumin, a yellow substance belonging to the polyphenols super family, is the active component of t...
Purpose: To evaluate the activities of new curcumin analogs as carbonic anhydrase II (CA-II) inhibit...
Dihydropyrimidinase is a member of the cyclic amidohydrolase family, which also includes allantoinas...
Aldehyde dehydrogenases (ALDHs) are responsible for the metabolism of aldehydes (exogenous and endog...
The anti-cancer properties of curcumin, the natural yellow pigment in the roots of turmeric (Curcuma...
Copyright © 2012 A. Kumar and U. Bora. This is an open access article distributed under the Creative...
Introduction: Curcumin (Diferuloylmethane) is a natural phenolic compound, which belongs to the curc...
Abstract. Curcumin has been widely reported as an anti-inflammatory agent isolated from the plant Cu...
In the present study, we aimed to dock 17 different ligands of curcumin analogues with that of human...
Aldehyde dehydrogenase 1 (ALDH1) is reported as a biomarker for identifying some cancer stem cells, ...
Abstract: Androgen receptor antagonists have been proved to be effective anti-prostate cancer agents...
Abstract: The antioxidative properties of a novel curcumin analogue (2E,6E)-2,6-bis(3,5-dimethoxyben...
Aldose reductase (ALR2) inhibition is the most legitimate approach for the management of diabetic co...
Objective: In the current study, an in silico approach has been utilized to investigate the anti-SAR...
A series of novel curcumin analogues has been designed, synthesized and tested in vitro/in vivo as p...
Curcumin, a yellow substance belonging to the polyphenols super family, is the active component of t...
Purpose: To evaluate the activities of new curcumin analogs as carbonic anhydrase II (CA-II) inhibit...
Dihydropyrimidinase is a member of the cyclic amidohydrolase family, which also includes allantoinas...
Aldehyde dehydrogenases (ALDHs) are responsible for the metabolism of aldehydes (exogenous and endog...
The anti-cancer properties of curcumin, the natural yellow pigment in the roots of turmeric (Curcuma...
Copyright © 2012 A. Kumar and U. Bora. This is an open access article distributed under the Creative...
Introduction: Curcumin (Diferuloylmethane) is a natural phenolic compound, which belongs to the curc...
Abstract. Curcumin has been widely reported as an anti-inflammatory agent isolated from the plant Cu...
In the present study, we aimed to dock 17 different ligands of curcumin analogues with that of human...