Validation of the German Revised Addenbrooke’s Cognitive Examination for Detecting Mild Cognitive Impairment, Mild Dementia in Alzheimer’s Disease

analyses. Results: The optimal cut-off score for the ACE-R for detecting MCI, AD, and FTLD was 86/87, 82/83 and 83/84, re-spectively. ACE-R was superior to MMSE only in the detec-tion of patients with FTLD [area under the curve (AUC): 0.97 vs. 0.92], whilst the accuracy of the two instruments did not differ in identifying MCI and AD. The ratio of the scores of the memory ACE-R subtest to verbal fluency subtest contributed significantly to the discrimination between AD and FTLD (optimal cut-off score: 2.30/2.31, AUC: 0.77), whereas the MMSE and ACE-R total scores did not. Conclusion: The Ger-man ACE-R is superior to the most commonly employed MMSE in detecting mild dementia in FTLD and in the differ-ential diagnosis between AD and FTLD. Thus it might serve as a valuable instrument as part of a comprehensive diag-nostic workup in specialist centres/clinics contributing to the diagnosis and differential diagnosis of the cause of de-mentia. Copyright © 2010 S. Karger AG, Base