Auditory oddball deficits in schizophrenia: an independent component analysis of the fMRI multisite function BIRN

Deficits in the connectivity between brain regions have been suggested to play a major role in the pathophysiology of schizophrenia. A functional magnetic resonance imaging (fMRI) analysis of schizophrenia was implemented using independent component analysis (ICA) to identify multiple temporally cohesive, spatially distributed regions of brain activity that represent functionally connected networks. We hypothesized that functional connectivity differences would be seen in auditory networks comprised of regions such as superior temporal gyrus as well as executive net-works that consisted of frontal-parietal areas. Eight net-works were found to be implicated in schizophrenia during the auditory oddball paradigm. These included a bi-lateral temporal network containing the superior and mid-dle temporal gyrus; a default-mode network comprised o