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Effect of different frequencies of fluoride dentifrice and mouthrinse administration: an in situ study Abstract: The effect of a combination of topical fluoridation methods for inhibition of enamel demineralization in the face of a cariogenic chal-lenge has not been clearly established. This in situ crossover study aimed to assess whether the addition of daily use of fluoride mouthrinse (FR) to that of fluoride dentifrice (FD) is equivalent to increasing the frequency of FD application in terms of the effect on enamel demineralization and fluoride content. Over 3 phases of 14 days each, 12 volunteers wore ap-pliances containing enamel blocks exposed to a 20 % sucrose solution 8 times/day. During each phase the blocks underwent one of the following treatments: 2x/day FD, 2x/day FD + 1x/day FR, and 3x/day FD. The blocks were assessed for hardness and fluoride content. Three x/day FD did not differ from 2x/day + 1x/day FR, however it enhanced deminer-alization protection when compared to 2x/day FD. All treatments pro-duced an increase in enamel fluoride content compared to no treatment (sound blocks) (p < 0.05), but the differences between them were not sig-nificant. The results of this study suggest that the daily use of fluoride mouthrinse combined with that of fluoride dentifrice has similar effects on enamel demineralization and fluoride content when compared to in-creasing the frequency of fluoride dentifrice use. Descriptors: Fluorides; Dentifrices; Mouthwashes; Dental Caries