DNA Methylation of SLC5A8, a Tumor Suppressor Gene in Chronic Myeloid Leukemia

Introduction: Almost all chronic myeloid leukemia (CML) patients have the Philadelphia (Ph) chromosome which is due to a reciprocal translocation, t(9;22)(q34;q11.2). Tumor suppressor genes (TSGs) are inactivated by DNA methylation at the CpG sites in their promoter regions, and this epigenetic alteration may play a role in the pathogenesis and progression of cancers and leukemias. The objective of this study was to profile the methylation status of TSGs in newly diagnosed CML patients i