[Hematology Reports 2013; 5:e2] [page 5] Thrombotic thrombocytopenicpurpura in a patient withinterferon treated hepatitis Csuccessfully treated withRituximab

Thrombotic thrombocytopenic purpura (TTP) is a life threatening condition associated with formation of platelet thrombi. Deficiency of ADAM TS 13 with presence of inhibitory anti-ADAM TS 13 Immunoglobulin G antibody is seen in patients with acquired TTP. TTP in patients on interferon therapy for chronic hepa-titis C has rarely been reported. Furthermore, successful treatment of an initial episode of acute refractory acquired TTP, in a patient of chronic hepatitis C during interferon therapy with Rituximab, has not been previously report-ed. Here we describe a case of acute refractory acquired TTP associated with pegylated inter-feron therapy for her chronic hepatitis C infec-tion. Initially refractory to plasmapheresis and steroids, she was successfully treated with Rituximab and plasmaphersis without any evi-dence of reactivation of hepatitis