Original Research Article Clinical Profile and Short Term and Long Term Outcome of Childhood

Objective- To evaluate the clinical and laboratory profile, short term and long term outcome of childhood haemolytic uraemic syndrome (HUS). Methods- Retrospective study of 33 episodes in 30 patients of HUS over a 11 years. Data on demography, duration of oliguria, requirement for and duration of dialysis, proteinuria, and severe hypertension and CNS involvement was recorded. On follow up the frequency of residual CNS impairment, proteinuria, blood pressure, GFR and deaths were noted. Results- The patients had a mean age of onset at 5.6 years, 3.6 years for D+ and 6.5 years for D-(p=0.04). Out of total 30 patients, 66 % (20/30) were D- and 33 % (10/30) D+. D- HUS had longer oliguria 24.7 days versus 9.4 days (p=0.03), dialysis16.4 versus 7.6 days (p=0.12) and hospital stay 36.4 versus 15.9 (p=0.05) than D+. Overall 50 % had nephrotic range proteinuria which was more common in D- than D+ (65 % versus 20%, p=0.02). Conclusion- D- HUS was seen in 66 % of cases and in older group and severe hypertension, proteiuria, and CNS involvement was common. They also had longer oliguria and more days on dialysis. Mortality was 20 % and 73.6 % of survivors had sequelae, proteiuria in 73%, hypertension in 63.5 %, eGFR less than 60 ml/min/m2 in 26.3%, CNS impairment in 21%. 82 % of D- HUS had sequelae. Key words- Hemolytic uraemic syndrome (HUS), renal failure, outcom