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Muscular dystrophies are a heterogeneous group of genetic mus-cle diseases characterized by progressive muscle weakness and atrophy. Cardiomyopathy and congestive heart failure or con-duction system abnormalities that cause arrhythmias, and sud-den cardiac death have been observed in muscular dystrophies. Despite the extensive research and ongoing clinical trials in mus-cular dystrophy to improve skeletal muscle pathology and func-tion, there is no effective treatment for this devastating disease. Existence of an association between lethal arrhythmias and signs of autonomic imbalance has initiated efforts to determine quan-titative markers of autonomic activity in neuromuscular diseases. To what extent unabated sympathetic overdrive contributes to the eventual demise of skeletal and cardiac muscle remains to be determined. These unexplored questions led us to compile this research topic entitled “Autonomic Regulation in Muscula