The aim of the study was to determine if immunomodulation of host defense with recombinant murine granulocyte colony-stimulating factor (G-CSF) improves the efficacy of trovafloxacin or moxifloxacin in ab-scesses containing Bacillus fragilis ATCC 23745 and different Escherichia coli strains varying in virulence. Treatment of mice inoculated with 107 CFU B. fragilis and 105 CFU low-virulence E. coli with either trova-floxacin (150 mg/kg/day every 24 hours, days 3 to 7) or moxifloxacin (96 mg/kg/day every 12 hours, days 3 to 7), significantly reduced the number of B. fragilis to 6.9 0.35 and 5.8 0.10 and that of E. coli to 4.9 0.09 and 4.2 0.07 log CFU/abscess for trovafloxacin and moxifloxacin, respectively, compared to controls (B. frag...
Mortality due to severe bacterial infections has not been markedly effected by the introduction of n...
The in vivo efficacy of JNJ-Q2, a new broad-spectrum fluoroquinolone (FQ), was evaluated in a murine...
ObjectiveTo investigate the in vitro potency and spectrum of activity of gatifloxacin and five compa...
The aim of the study was to determine if immunomodulation of host defense with recombinant murine gr...
Item does not contain fulltextThe pharmacodynamic and pharmacokinetic properties of trovafloxacin we...
AbstractBackground:In intra-abdominal infections, the activity of antimicrobial agents against Bacte...
: Infections that occur after intraabdominal surgery still cause considerable morbidity and mortalit...
Contains fulltext : 142705.pdf (publisher's version ) (Closed access)The aim of th...
Objectives: To compare the efficacy of moxifloxacin, gatifloxacin and ciprofloxacin for the post-exp...
The aim of the present study was to assess the influence of immunomodulation of host defense with re...
We investigated the antimicrobial activity of a fluoroquinolone against two genetically close bacter...
We evaluated the protective effect of fosfomycin (FOM) and an enantiomer of fosfomycin [FOM(1); an i...
Antimicrobial agents of the fJ-Iactam class were examined for relative efficacy against Bacteroides ...
Burkholderia pseudomallei, the causative agent of melioidosis, is an important pathogen in tropical ...
International audienceBACKGROUND: Alternative treatments are needed against NDM-1-producing Escheric...
Mortality due to severe bacterial infections has not been markedly effected by the introduction of n...
The in vivo efficacy of JNJ-Q2, a new broad-spectrum fluoroquinolone (FQ), was evaluated in a murine...
ObjectiveTo investigate the in vitro potency and spectrum of activity of gatifloxacin and five compa...
The aim of the study was to determine if immunomodulation of host defense with recombinant murine gr...
Item does not contain fulltextThe pharmacodynamic and pharmacokinetic properties of trovafloxacin we...
AbstractBackground:In intra-abdominal infections, the activity of antimicrobial agents against Bacte...
: Infections that occur after intraabdominal surgery still cause considerable morbidity and mortalit...
Contains fulltext : 142705.pdf (publisher's version ) (Closed access)The aim of th...
Objectives: To compare the efficacy of moxifloxacin, gatifloxacin and ciprofloxacin for the post-exp...
The aim of the present study was to assess the influence of immunomodulation of host defense with re...
We investigated the antimicrobial activity of a fluoroquinolone against two genetically close bacter...
We evaluated the protective effect of fosfomycin (FOM) and an enantiomer of fosfomycin [FOM(1); an i...
Antimicrobial agents of the fJ-Iactam class were examined for relative efficacy against Bacteroides ...
Burkholderia pseudomallei, the causative agent of melioidosis, is an important pathogen in tropical ...
International audienceBACKGROUND: Alternative treatments are needed against NDM-1-producing Escheric...
Mortality due to severe bacterial infections has not been markedly effected by the introduction of n...
The in vivo efficacy of JNJ-Q2, a new broad-spectrum fluoroquinolone (FQ), was evaluated in a murine...
ObjectiveTo investigate the in vitro potency and spectrum of activity of gatifloxacin and five compa...