Original Research Article Expression of Beta Catenin in Sudanese Women with Breast Cancer

Study Design and Objective: this was a retrospective descriptive study aimed to identify expression of beta catenin in breast tissue obtained from Sudanese women with breast cancer. Material and Methods: hundred formalin-fixed paraffin-embedded tissue blocks of breast cancer were included in this study. Tissue sections were stained using monoclonal antibody for Beta catenin, interpreted by a light microscope, and results analyzed by SPSS program and correlated with the available clinicopathological data. Results: The beta catenin expression was positive in 68 % of cases and negative in 32 % of cases. The expression of beta catenin was positive in 82 % of Triple Negative Breast Cancers (TNBCs), 29 % of Triple Positive Breast Cancers (TPBCs), 96 % of Her2 tumors, 56 % of luminal- A tumors, and 29 % of luminal- B tumors. Conclusion: Increased expression of beta catenin in triple negative cancer, Her2 positive cancer, and high grade tumors confirms its importance as a prognostic marker for breast cancer. Key Words: beta catenin; breast cancer