Case Report Autoimmune Hemolytic Anemia Induced by Levofloxacin

License, which permits unrestricted use, distribution, and reproduction in anymedium, provided the originalwork is properly cited. Drug-induced autoimmune hemolytic anemia is a rare condition. We report the case of a 32-year-old white female who presented to the emergency department with generalized fatigue, fever, and jaundice. The patient reported using levofloxacin few days prior to presentation for urinary tract infection. The patient had evidence of hemolytic anemia with a hemoglobin of 6.7 g/dL which dropped to 5 g/dL on day 2, the direct Coombs test was positive, indirect bilirubin was 5.5mg/dL, and LDH was 1283 IU/L. Further testing ruled out autoimmune disease, lymphoma, and leukemia as etiologies for the patient’s hemolytic anemia. Levofloxacin was immediately stopped with a gradual hematologic recovery within few days. 1. Case Report Fluoroquinolones have become an increasingly popular class of antibiotics for use in a variety of infections. Although they are very useful agents, they are associated with a number of adverse events and some with considerable clin-ical significance. Levofloxacin is a third-generation fluoro-quinolone with a broad spectrum of activity against Gram-positive and Gram-negative bacteria and atypical respirator