Research Article Effect of GAS6 and AXL Gene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents

Copyright © 2014 Fone-Ching Hsiao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The present study was designed to explore the effects of GAS6 and AXL gene polymorphisms on adiposity, systemic inflammation, and insulin resistance in adolescents. After multistage sampling from the data of the Taipei Children Heart Study-III, we collected 358 boys and 369 girls with an average age of 13.3 years. We genotyped the adolescents ’ GAS6 rs8191973, GAS6 rs8191974, AXL rs4802113, andAXL rs2304232 polymorphisms. Significantly higher bodymass index (BMI), waist circumference (WC), and hsCRP levels were found in boyswith theGGgenotype ofGAS6 rs8191974 thanA allele carriers; higher IL-6 and insulin levels and increased HOMA-IR were found in boys with the GG genotype ofAXL rs2304232 than the A allele carriers.There was a significant difference in hsCRP levels of boys with the TT, TC, and CC genotypes of AXL rs4802113. Boys with both the GG genotype of GAS6 rs819197