Original Research Article Evaluation of Percentage of Change in Plasma NT-ProBNP Level Following Treatment of Acute Heart Failure Syndromes- A Prospective Clinical Study

Background and aims: N-terminal pro brain natriuretic peptide (NT-proBNP) is known to aid intensive care unit diagnosis of Acutely Heart Failure Syndromes. Our aim was to study the percentage change in Plasma NT-proBNP level following treatment of Acute Heart Failure Syndromes and to establish time basis for measuring the second Plasma NT-proBNP. Methodology: This study was conducted in 36 patients admitted with Acute Heart Failure Syndromes in Dr B R A M Hospital and Pt J N M Medical College. All the patients underwent comprehensive clinical evaluation and necessary investigations. Plasma NT-proBNP analysis was done twice in each patient, initially at the time of admission and later either at 72 hrs if patient had improved or else at the time of discharge. Results: In our study, 22 (61.12%) patients showed more than 50 % decrease in NT-proBNP values after treatment. While 5 (13.88%) patients showed 30-50 % decrease in NT-proBNP values. Remaining 9(25%) patients showed less than 30 % change in NT-proBNP values. Also, we found statistically significant reduction in plasma NT-proBNP following treatment at 72 hrs as compared to baseline (p<0.0001). Conclusion: In our study, majority of patients showed significant reduction in plasma NT-proBNP levels following treatment and majority of them did it within 72 hrs