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Despite some evidence for the effectiveness of homeopathy from large-scale observational studies [1–4], the question whether its clinical effects are completely due to placebo re-mains subject of scientific debate [5, 6]. The scepticism to-wards homoeopathy mainly results from the lack of a general-ly accepted scientific rationale of its action [7]. If everything that exists beyond a clearly defined physiological mechanism, e.g. drug-receptor interaction, is considered to be a placebo, then, at present, this is true for homeopathy. In contrast, Samuel Hahnemann, the founder of homeopathy, spoke of the vital force or ‘dynamis ’ as target of action of homeopathic remedies [8]. Modern homeopaths might argue that the remedy transports some kind of ‘information ’ [9] that is able to stimulate the ‘healing capacities ’ of the organism [10]. As we will point out, these explanation models are prett