Mechanisms and treatment

REVIEW Auto-positive end-expiratory pressure (auto-PEEP) is a common problem in patients receiving full or partial ventilatory support, as well as in those ready to be weaned from the ventilator. Physicians should be alert for it and take measures to reduce it, as it can have serious consequences. ■ KEY POINTS Auto-PEEP occurs much more frequently than was previously thought. Auto-PEEP and dynamic hyperinflation may cause significant discomfort and precipitate patient-ventilator asynchrony through several mechanisms. Auto-PEEP increases the work of breathing and ca