Tissue Penetration of Telavancin after Intravenous Administration in Healthy Subjects

The pharmacokinetic disposition of telavancin administered 7.5 mg/kg of body weight every 24 h was determined in plasma and skin blister fluid. The mean penetration of telavancin into blister fluid was 40%. This study reveals that adequate concentrations are achieved in both plasma and blister fluid for pathogens frequently implicated in skin and soft tissue infections. Telavancin is a semisynthetic glycopeptide antibiotic cur-rently undergoing development for the treatment of infections caused by clinically important gram-positive bacteria (5). Due to the concern of rising resistance rates among gram-positive pathogens, the development of new antibiotics with the ability to overcome current resistance mechanisms is essential. Tela-vancin displays rapid, bactericidal, concentration-dependent activity against clinically important gram-positive aerobic pathogens, such as Staphylococcus aureus (methicillin suscep-tible and methicillin resistant) (3, 8, 10). Telavancin exhibits its killing effects via multiple mechanisms of action, includin