Case Report: Yunis Varon

We have reported a case of Yunis-Varon syndrome which is a rare, autosomal recessive syndrome characterized by growth retardation, defective growth of the cranial bones, characterist-ic facial features, abnormalities of the fingers and/or toes & cl-eidocranial dysplasia. Additional features in this case were patent ductus arteriosus, CT brain findings suggestive of ischemic changes, CSF examination suggestive of pyogenic meningitis & cystic changes in right adrenal gland. Key Words: Yunis-Varon syndrome, distal aphalangea Case Report: A male neonate weighing 2.9 kg was born at full term by spontaneous vaginal delivery to a 25-year-old gravida 6 moth-er. There was no history of consanguineous marriage. The mother gave history of having given birth to an earlier 2 fe-male babies with dysmorphic features who had died on day 11 of life. The antenatal period was unremarkable. The neonate did not require resuscitation at birth and developed respiratory distress soon after. Clinical features seen in the patient were as follows: • Microcephaly • Sparse scalp hair, eyebrows & eyelashes • Short up-slanting palpebral fissures • Anteverted nares • Labiogingival retraction • High arched palate • Short philtrum • Thin lips • Cupid bow like upper lip • Low-set & dysplastic ears • Loose nuchal skin • Micrognathia • Agenesis/hypoplasia of thumbs & great toes • Short tapering fingers & toes • Nail hypoplasia • Agenesis/hypoplasia of distal phalanges of fingers & toes, 1st metatarsals • Simian crease (left side) • External genital abnormality (hydrocele) • Hazy cornea • Bilateral nuclear cataract • Mild ocular hypertelorism • Patent ductus arteriosus • Right suprarenal cystic lesio