Association between chemerin rs17173608 polymorphism and obesity in Iranian women

Chemerin is a novel adipokine that regulates adipogenesis and adipocyte metabolism. Circulating levels of chemerin significantly correlated with body mass index (BMI) and obesity. In this study, we investigate the association of chemerin rs17173608 polymorphism and obesity risk. A total of 300 Iranian women was subjected to genotyping. Genotype determination was performed by tetra-amplification refractory mutation system-PCR (T-ARMS PCR) method. Our finding showed a significant association between GT (OR:2.8, 95 % CI: 1.6-4.9, P<0.001) and GG (OR: 8.4, 95 % CI: 2.1-33.8, P: 0.003) genotypes with overweight and obesity respectively. In the dominant genetic model (comparison of GT+GG vs. TT), GT+GG genotypes showed increased risk of overweight and obesity. Here we suggest that, for the first time, chemerin rs17173608 polymorphism is significantly associated with overweight and obesity in Iranian women