EFFECT OF MODE OF ADDITION OF DISINTEGRANTS ON DISSOLUTION OF MODEL DRUG FROM WET GRANULATION TABLETS

The purpose of the study was to formulate immediate release tablets using various types of disintegrants (crospovidone, sodium starch glycolate and sodium carboxymethylcellulose), in order to investigate the effect of mode of incorporation of disintegrants on release mechanism from tablets. Acetaminophen, a poor soluble drug was used as a model drug to evaluate its release characteristics from different formulations. The USP paddle method was selected to perform the dissolution profiles carried out by USP apparatus 2 (paddle) at 50 rpm in 900 ml phosphate buffer pH 5.8. Successive dissolution time, time required for 25%, 50 % and 80 % of the drug release (T25%, T50%, T80%) was used to compare the dissolution results. A One way analysis of variance (ANOVA) was used to interpret the result. Statistically significant differences were found among the drug release profile from all the formulations except mode of addition of crosspovidone. At a fixed amount of disintegrants, extragranular mode of addition seemed to be the best mode of incorporation. The best release was achieved with the crospovidone containing formulations. The T50 and T80 values were indicative of the fact that the drug release was faster from tablet formulations containing crosspovidone. The drug release was very much negligible difference by the mode of crospovidone addition. Two formulations found very small T50 and T80 values indicating very much faster release. From the all formulations corresponded extragranular mode o