Invasion Migration

truc on t, ut ells) Moreover, a dramatic delay in tumor progression was observed in MCF-7/cav-1 cells as compared with al mem e coat rgeted as end dropl advanced stages of specific malignancies, suggesting a role in cancer promotion [8,9]. Disparate results have also been obtained with respect to the regulation of apoptosis in cells and tissues, with caveolin capable of functioning either as a facilitator or suppressor [10–13], suggesting that caveolin-1 has distinct cell type-specific tumor-modulating functions, either 7/cav-1 cells are well documented in vitro, including soft agar col-ony formation and invasion activity through a filter membrane coated with Matrigel, the growth characteristics of MCF-7/cav-1 cells in vivo are currently unknown. Thus, we decided to conduct xenograft experiments in nude mice in order to shed light on the biological significance of caveolin-1 expression in MCF-7 cells. In the current study, we stably expressed caveolin-1 in MCF-7 cell lines lacking endogenous expression of caveolin-1 and found that MCF-7/cav-1 cells exhibited reduced migration in vitro as well as a decreased ability to form tumors following inoculation in nude mice