Indian Journal of Clinical Biochemistry, 2006 83 EFFECT OF OBESITY AND INSULIN RESISTANCE ON DIABETIC CONTROL

Diabetes Mellitus in obese and non-obese Indian individuals. AIMS: Effect of Obesity and insulin resistance on diabetic control. SETTINGS AND DESIGN: 50 each groups Diabetic individuals obese and non-obese. METHODS AND MATERIAL: On selected 50 each group diabetic patient and normal, following blood investigations has been performed- Plasma Glucose, Glycohemoglobin and Serum Insulin. STATISTICAL ANALYSIS USED: Individuals patient’s results were analyzed and compared with the normal controls. RESULTS AND CONCLUSION: The changes in glycosylated haemoglobin are mainly proportional to the post lunch glucose level (r = 0.773) (p < 0.01) and not correlated to circulating insulin or the body mass index. However the levels were higher in obese diabetes (Type I and II both) than in non-obese. Mechanism of resistance in insulin receptor interactions due to obesity is well known. However, obesity does not seem to affect directly glycosylated haemoglobin. Under such circumstances, the reduction of weight for a diabetic person can improve sugar control by minimizing insulin resistance and thereby can improve glycosylated haemoglobin levels