Exploration of prehospital vital sign trends for the prediction of trauma outcomes

Objectives. We explored whether there are diagnostically useful temporal trends in prehospital vital signs of trauma patients.Methods. Vital signs were monitored during trans-port to a level I trauma center and electronically archived. Retrospectively, we identified reliable vital signs recorded from the 0- to 7-minute interval and from the 14- to 21-minute interval during transport, and, for each subject, we computed the temporal differences between the two inter-vals ’ vital signs, the intrasubject 95 % data ranges, the val-ues during the initial 2 minutes, and the 21-minute overall means.We tested for differences between subjects withmajor hemorrhage versus control subjects, and computed receiver-operating characteristic (ROC) curves. We conducted sensi-tivity analyses, exploring alternative clinical outcomes, tem