Effect of Fluoride on the Morphology of Calcium Phosphate Crystals Grown on

of dental enamel to extreme acidic pH in the oral cavity, either from extrinsic sources (diet) or intrinsic factors (reflux disorders), leads to dental erosion [Meurman and ten Cate, 1996; Lussi et al., 2004; Honório et al., 2008]. Dental erosion, which is the loss of enamel mineral due to acidic exposure not involving bacteria, has been di-rectly associated with disorders such as bulimia nervosa and chronic gastroesophageal reflux [Nunn, 1996]. In the last five decades, fluoride has been used for the treatment of dental erosion and caries prevention through different modalities [ten Cate, 1997]. In addition, the ef-fect of fluoride on the nanostructure of remineralized apatite has been well documented [Aoba, 1997; Robinson et al., 2004]. However, the optimal dose of fluoride result-ing in a positive effect on enamel hydroxyapatite remin-eralization with minimum risk of toxicity has not been well documented. A future alternative approach to treat affected enamel would be strategies to reconstruct a synthetic enamel-like structure of hydroxyapatite nano-rods from supersatu-rated calcium phosphate solution [Yamagishi et al., 2005; Zhan et al., 2005; Chen et al., 2006; Ye and Wang, 2007]. Methods used in the past by various investigators in-volved extreme conditions such as the application of high temperature, high pressure, or extreme acidic conditions, which are not practical in the clinical setting. The pres-ence of 0.1–2 mg/l fluoride in the mineralization solutio