ABSTRACTS 2014 AMERICAN NEUROPSYCHIATRIC ASSOCIATION ANNUAL MEETING ABSTRACTS P1. Frontolimbic Neural Circuit Changes Associated With Clinical Improvement Following Transference- Focused Psychotherapy in Borderline Personality Disorder

Background: Borderline personality disorder (BPD) is char-acterized by deficits in self-regulation, including impulsivity and affective instability. Transference-focused psychotherapy (TFP) is an evidence-based treatment with proven effective-ness in reducing symptoms across multiple cognitive-emotional domains in patients with BPD. In this study, longitudinal changes in neural activation patterns and predictors of treatment response were investigated using a dimensional symptom-based approach. Methods: A functional magnetic resonance imaging (fMRI) activation paradigm was used pre and post-TFP in patients with BPD, with statistical parametric analyses, to test hypotheses concerning the identification of frontolimbic biomarkers for clinical improve-ment. Using a within-subjects design, BPD subjects (N510; mean age527.8) were scanned pretreatment, and again afte