ORIGINAL CONTRIBUTION Association of White Matter Hyperintensity Volume With Decreased Cognitive Functioning The Framingham Heart Study

terhyperintensity (WMH)volumeonmagnetic resonance imagesandcognitivetestsinalarge,population-basedsample. Methods:Quantitativemagnetic resonance imaging and neuropsychological evaluations were performed in 1820 dementia- and stroke-free participants from the Framing-hamOffspringCohort. TheWMHvolume relative to total cranial volumewas computed;WMHvolumesmore than 1 SD above the age-predictedmeanwere defined as large. Adjusting for age, sex, education, height, and Framing-ham Stroke Risk Profile, we examined the relationship betweenWMHand3 cognitive factors derived fromaneu-ropsychological test battery (verbal memory, visuospa-tial memory and organization, and visual scanning and motor speed) and 3 individual measures of new learn-ing, abstract reasoning, and naming