Microstructured extracellular matrices in tissue engineering and development

Associate Editor Tzung Hsiai oversaw the review of this article. Abstract—Microstructured extracellular matrix (ECM), which contains heterogeneous features of the same size scale (5–100 lm) as tissue organoids, has become an important material for the engineering of functional tissues and for the study of tissue-level biology. This review describes methods to generate this class of ECM, and highlights recent advances in the application of microstructured ECM to problems in basic and applied biology. It also discusses computational techniques to analyze and optimize the microstructural patterns for a desired functional output