Sequence Mutations of Genes Pertaining to Malignancy in Cancer

Abstract: Cancer is a complex disease where various types of molecular aber-rations drive the development and progression of malignancies. Among the diverse molecular aberrations, inherited and somatic mutations on DNA se-quences are considered as major drivers for oncogenesis. The complexity of somatic alterations is revealed from large-scale investigations of cancer genomes and robust methods for interring the function of genes. In this review, we will describe sequence mutations of several cancer-related genes and discuss their functional implications in cancer. In addition, we will in-troduce the on-line resources for accessing and analyzing sequence mutations in cancer. We will also provide an overview of the statistical and computa-tional approaches and future prospects to conduct comprehensive analyses of the somatic alterations in cancer genomes. Key words: Cancer, cancer databases, mutations. 1