Additional File 2: Data Country level EIR:

Data on the proportion of children aged 2-10 with Plasmodium falciparum parasites (PfPR2-10) in 2007 was published at a 5km grid scale by Hay et al in 2009 [1]. Subsequent work developed a methodology for summarising this data at the country level by weighting it by the population at the 5km grid scale [2]. For the purposes of this analysis we required an estimate of the country-level entomological inoculation rate (EIR), per year. To do this, the parasite rate (PfPR2-10) was first transformed to EIR using a previously published estimate of the non-linear relationship between these parameters [3], as illustrated in Figure S1, below. Once the conversion of PfPR2-10 to EIR had been made at the 5km scale it was converted to the country-level EIR using the population weighting methodology previously described by Gething et al [3]. Figure S1: The non-linear relationship between EIR and prevalence of Plasmodium falciparum parasites in 2–10 year olds derived by fitting a transmission model to a range of data [3].(Note: In Figure 1 of Griffin et al (2010) a similar relationship is shown between EIR and prevalence in under 15 year olds, which is estimated by fitting the model to a number of datasets giving prevalence in different age groups. This plot is the resulting relationship between EIR and prevalence in 2-10 year olds, for the same parameter values)