Synthesis and Antimicrobial Evaluation of 4-Amino/Dimethylamino-1-Aryl/Alkylpyridinium Bromide

A series of bromides (RCH2Br) containing aryl / alkyl group readily reacted with 4-amino / dimethylaminopyridine to give stable pyridinium bromide (1-30). The physical and spectral (IR, 1H & 13C NMR and MS) data for 1-30 were collected to confirm the structure (s) assigned. Invitro antibacterial and antifungal activities of 1-30 against Gram positive / Gram negative and fungal species were evaluated. The 4-amino / dimethylamino-1-alkylpyridinium bromides (Group III & IV) were found higher antibacterial and antifungal activity than the standard drugs ciprofloxacin / fluconazole respectively