RESEARCH Promoter methylation and

gene in gastric cancer ai common malignancies in the world. Disease development in gastric cancer is a multi-stage process that involves more may occur through various channels. In addition to dele-tions and mutations, aberrant changes in DNA methylation Guan et al. Diagnostic Pathology 2013, 8:110 http://www.diagnosticpathology.org/content/8/1/110expression is inhibited in this region [3]. The inactivation ofUniversity, 155 Nanjing Beijie, Heping Section, Shenyang, Liaoning Province 110001, Chinathan one gene. Disease factors ultimately act on different genes at different stages, causing a change in gene structure are considered as the third mechanism leading to anti-oncogene inactivation [1,2], which plays an essential role in tumor development. CpG islands, which are CpG-rich sequences located in the upstream promoter region of a housekeeping gene, are regions at which cytosine methyla-tion does not generally occur, although stimulation by cer-tain factors leads to its methylation. Consequently, DN