A Study on Assessment and Comparison of Anti Diabetic effect of Monotherapy and Combination Therapy involving in Metformine and Glimipride

Diabetes mellitus (DM) is a complex metabolic disorder and which is one of the major health crisis the world facing today. There is no permanent cure for DM, however. It could be managed successfully with existing oral hypoglycaemic agents and insulin. Most of the time diabetic management will be unsuccessful in outpatients because of lack of health consciousness of the patients leading to noncompliance of advises given by physician and pharmacist. The main objective of the present study was to monitor three groups of Type-2 DM patients through frequent patient counselling and plasma glucose level monitoring using commercial self monitoring blood glucometer (SMBG). Patients were advised to take single or combination of Metformine or Glimipride for up to 24 weeks. Blood glucose levels were assessed at fasting and post prandial condition using SMBG. The results indicate that both single and combination therapy significantly reduces the DM complications. However the combination therapy provided better improvement of DM complications as compare to single drug treatment. More drugs related adverse effects were observed in combination therapy. The study reveals that the better clinical patient compliance of diabetic management could be achieved with proper and frequent patient counselling