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Full list of author information is available at the end of the articleIntroduction Major advances have been made in the prevention, diag-nosis, and treatment of cardiovascular disease (CVD) over the last four decades. This has contributed to a reduced mortality, however, morbidity and mortality from CVD remains high with prevalence estimates in the United States at approximately 82.6 million. In 2008, heart disease and cerebrovascular disease were the first and fourth leading causes of death, respectively. The total cost of CVD is an economic burden on health care with an esti-mated total cost of $298 million [1]. The prevention of CVD has become a public health initiative with many at-tributing variables, of which includes the consumption of fish and fish-derived omega-3 fatty acids [2-4]. Both ran-domized clinical interventions and observational studie